The Wall Street Journal published “Most Antidepressants Aren’t Effective for Children, New Study Finds” on 6-27-16. This thorough article discusses a metal analysis of 34 medication trials for children with depression, published by Lancet, and which found, “among 14 regularly prescribed antidepressants only fluoxetine—brand name Prozac—was more effective than a placebo and had benefits that outweighed harms.” And, Prozac was found to be “only moderately helpful.”

The article also notes that most current treatment guidelines for children with depression recommend therapy, such as CBT or Interpersonal Therapy, is the first line of treatment.  The lead author of the study, Andrea Cipriani, MD, reportedly plans to do follow up research comparing the effectiveness of medication and therapy for depressed children.

The article also notes that the American Academy of Pediatrics recently updated its clinical guidelines for children with suicidal risk, and concluded, “the benefits of antidepressant medications outweigh the risks” for this population.

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